Tottenham will be without Ledley King for the FA Cup fifth-round replay with Bolton because of a thigh injury.
Aaron Lennon also misses out after suffering a setback in his recovery from a groin problem, while Younes Kaboul and Kyle Walker are cup-tied.
Bolton boss Owen Coyle could be tempted to rotate his squad with his side in the midst of a relegation battle.
Vladimir Weiss and Jack Wilshere are cup-tied, while Gretar Steinsson, Chris Basham and Mark Davies are injured.
And that could mean the likes of Stuart Holden, Jlloyd Samuel, Tamir Cohen, Andy O'Brien, Ali Al Habsi and Mustapha Riga all feature, with Coyle saying: "The priority is to stay in the Premier League.
"If somebody was to say me 'would you give up the FA Cup to stay in the Premier League?' the answer to that is yes - it remains our number-one aim.
"But I believe we can stay in the Premier League and progress in the FA Cup.
Are Tottenham Hotspur the favourites to win? Absolutely. Can we go there and win? Of course we can, so we'll go there and look to try and take the game to them in a positive manner."
Bolton are likely to have to face Roman Pavlyuchenko in the Spurs attack, just three days after his two-goal salvo helped the Londoners beat Wigan on Sunday.
And Redknapp is tipping the Russian, who has been out of favour for long spells this season leading to speculation he wants to leave the club, to fire Tottenham into the quarter-finals and an away tie at Fulham.
"When he is in the right frame of mind and comes on like he did on Sunday, I have always said he is a fantastic talent with great ability," he said.
"If he can score some goals for us between now and the end of the season to take us where we want to go, then that will be a real bonus for us.
"When he is at his best, he is a top player - he has played at World Cups and, if he can do that for us, it will be great.
"I also need to give Eidur a chance to play as well, because he has been great in training. He is another player who is very much in my mind."
Tottenham (from): Gomes, Dawson, Bassong, Bale, Corluka, Huddlestone, Bentley, Palacios, Modric, Kranjcar, Crouch, Defoe, Alnwick, Gudjohnsen, Pavlyuchenko, Dervite, Rose, Parrett, Fredericks.
Bolton (from): Jaaskelainen, Steinsson, Knight, Robinson, Gardner, Cohen, Taylor, Muamba, Lee, K Davies, Klasnic, Riga, A O'Brien, Al Habsi, Samuel, Elmander, Ricketts, Holden.
Match officials
Referee: Peter Walton (Northamptonshire)
Assistant referees: Nigel Bannister & Ron Ganfield
Fourth official: Grant Hegley BIG-MATCH FACTS
The tie in context
• This is one of two replays that will see one of the nine remaining Premier League clubs eliminated.
Gulf in class
• Third-bottom Bolton are 14 places lower than Spurs.
Fifth Round draw
• Prize for the winners will be an away tie to fellow top-flight Fulham in the quarter-finals on Saturday, 6 March.
Head-to-head
• Tottenham came from behind to earn this replay.
• Both this season's Premier League and FA Cup meetings at the Reebok were drawn.
• Tottenham have not lost to the Trotters at White Hart Lane since an odd goal in seven League Cup reverse in October 2004
• This is the sixth season these clubs have met each other in the history of the FA Cup; only twice has the issue been resolved at the first time of asking.
The clubs
TOTTENHAM HOTSPUR
Current form
• Avoided defeat in seven of the last eight in all competitions.
• Looking for an eighth successive home game without defeat, since the shock loss to Wolves on 12 December.
• Eidur Gudjohnsen, who has only made one appearance for Tottenham this season, is a former Bolton player.
FA Cup form
• Since reaching the last eight in 2007, Spurs have not managed to get past the fourth round.
BOLTON WANDERERS
Current form
• Not won in six (D3, L3).
• Scored only one goal in six outings.
• Chasing a first victory in 12 league and cup games on the road, since their 2-1 winning visit to Birmingham on 26 September.
FA Cup form
• Having won an FA Cup tie for the first time in three years, the Trotters are now on their best run since 2005/06.
• The four-times winners last qualified for the quarter-finals in 2005; their only appearance in the last eight in nine seasons.
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